Lincosamides
Материал из Поле цифровой дидактики
Версия от 21:11, 22 сентября 2022; Patarakin (обсуждение | вклад) (Новая страница: «{{Antibiotics |Description=Lincosamides are antibiotics used mainly to treat G + infections. These include lincomycin and clindamycin. Older lincomycin is no longer used in practice. |Mechanism of action=Lincosamides inhibit protein synthesis by binding to the 50S subunit of the ribosome. |Antimicrobial spectrum=It acts mainly on G + bacteria such as staphylococci and streptococci. They are also effective against anaerobes, some G− rods. Clostridium diffic...»)
| Описание | Lincosamides are antibiotics used mainly to treat G + infections. These include lincomycin and clindamycin. Older lincomycin is no longer used in practice. |
|---|---|
| Механизм действия | Lincosamides inhibit protein synthesis by binding to the 50S subunit of the ribosome. |
| Спектр действия | It acts mainly on G + bacteria such as staphylococci and streptococci. They are also effective against anaerobes, some G− rods. Clostridium difficile, Neisseria, hemophilia and others are resistant. |
| Фармакокинетика | Clindamycin after administration absorbs well. Penetrates body fluids and tissues, including bones. However, the penetration into the cerebrospinal fluid is small. It is excreted by the kidneys. |
Clindamycin is one of lincosamides, which are antibiotics used as an alternative in the treatment of infections caused by gram-positive and anaerobic bacteria in patients hypersensitive to penicillins or other β-lactam antibiotics.
